Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution. The hexane, ethyl acetate, conerea n -butanol extraction yields were, respectively, 1. Sports Turf Research Institute. Oils, Volatile Search for additional papers on this topic. Material and Methods 2.

Flavonoids from Cotula cinerea Del

The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene. Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc. The antiproliferative activity of Cotula cinerea essential oil against the Vero tumor cell line could be due to presence of cytotoxic molecules in the oil.

The Royal Society of New Zealand. The evaluation of cell viability has been achieved through the use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay. For both lines, an increase of the cytotoxicity with the concentration of the essential oil or the used extracts was observed indicating a dose dependent effect. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca.


This genus was first mentioned by Carl Linnaeuswho described four species in his first edition of Species Plantarum. These plants are widely used in the Moroccan traditional folk medicine. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. In the genus was subdivided by George Bentham [5] into three sections. Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.

Cotula cinerea which is of the Asteraceae family is a xerophytic plant widely distributed in sandy and desert grounds [ 11 ].

The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products. Furthermore, natural products could be as efficient as synthetic ones with no or less toxicity and are less expensive than synthetic drugs. The tentative global mechanism gathered probably all these actions which are thus supposed to provide the observed cytotoxic effect.

Another characteristic is their solitary heads growing on a peduncle. Cotula is known to be used in Cotu,a Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7]. In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts.

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This study is expected thus to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further exploration on other types of cancer cell lines. From This Paper Figures, tables, and topics from this paper. Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae. Most are disciform lacking ray florets.

Cotula vulgaris Levyns Cotula zeyheri Fenzl. The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea. The concentrations that inhibit half of the cell population IC 50 were obtained by modeling the percentage of cytotoxicity versus concentration of extracts. The plant is widely distributed in Morocco and is widely used in Moroccan cinsrea folk medicine as a cholagogue, antiseptic, diuretic, and astringent [ 12 ].

This was observed for both cell lines. Cootula addition, these mixtures could act in a synergic or in an antagonism dotula. These compounds could explain the cytotoxic effect of this extract on RD tumor cell line. The noticed differences in the observed cytotoxicity of the investigated mixtures could obviously be due to the phytochemical composition of each extract. Subscribe to Table of Contents Alerts.